Question

aromatic group(benzene 6c) and alkyl group(6c) which one is more lipophilic? i assume that it is alkyl group but how to justify it

Answer 1

@Photon336 @sweetburger can help with this question? sorry to bother you guys

Answer 2

pls help

Answer 3

can i relate it to the pi electrons, but how to explain in a proper way?

Answer 4

let's look up the requirements for lipo-philic. Well, I like to think of philic as favoring something" so the compound likes to dissolve in lipids/fats.

Answer 5

Well, lipids are both hydrophobic and hydrophilic. So based off my understanding, both molecules would interact with the lipid in some way. I'm wondering if there is more to this question? Pi electrons are delocalized with the pi system. This means that the electrons are free to move around in that conjugated pi system. It means they don't really like to react because of that stability.

Answer 6

but according to my understanding lipophilic is somewhat similar to hydrophobic interaction. From the lab result of phenobarbitone and quinalbarbitone, it is found out that quinalbarbitone is more lipophilic than phenobarbitone. So, my explanation is that phenobarbitone has the benzene ring which will form pi stacking, forming positive induced and negative induce dipole