Question

The instructions on the tPA vials read to reconstitute with 50 mL of sterile water to make a total of 50 mg/50 mL (1 mg/mL). The hospital is to infuse 0.9 mg/kg over 60 minutes with 10% of the dose given as a bolus over 1 minute. N.T. weighs 143 pounds. What is the amount of bolus dose, in both milligrams and millimeters, you will administer in the first minute? What is the amount of the remaining dose that you will need to administer?

Answer 1

First convert 143 lbs to kgs -----> about 64.86 kgs
Then multiply by 0.9 to get necessary amount in mg ----> 58.37 mg

The total dose then is 58.37 mL mixed with 58.37 mg.
10% = 5.837 mg
Remaining dose = 52.54 mg over 59 minutes

Answer 2

THANK YOU!