Question

An animal ingests a plant that contains a toxic compound known to interfere with the Krebs (Citric Acid) Cycle. Which of the following is/are likely outcomes of this ingestion? You may need to select more than one answer.

Answer 1

a
The animal cannot survive due to lack of ATP production.
b
Oxidative phosphorylation will no longer occur, resulting in overall less ATP.
c
The animal continues to survive on ATP produced through glycolysis alone.
d
The Krebs (Citric Acid) Cycle will continue as usual.

Answer 2

@AZ

Answer 3

is one of the options A?

Answer 4

az?

Answer 5

i need it fast

Answer 6

az?

Answer 7

@Astrid1 @Extrinix

Answer 8

mhmm I'm really doubting if there is more than one correct answer now

Answer 9

ill pick A and B

Answer 10

okay, well actually let's see

so there are Citric acid deficiencies that are rare and can occur

any metabolic disorder for the most part is going to end up being fatal unless it can be managed/treated so A is correct

however Krebs cycle is separate from oxidative phosphorylation so why do you think something interfering with Krebs cycle would make oxidative phosphorylation not occur?

Answer 11

there has to be more then on choice and A is related to B but if its C then it has to be C and D

Answer 12

i have to anser really fast so i can just guess

Answer 13

az?

Answer 14

so can the Krebs cycle continue as normal if there's something interfering with it?

Answer 15

it cant

Answer 16

so it's definitely not D

Answer 17

`Fluoroacetate produces its toxic action (after conversion to fluorocitrate) by inhibiting the Krebs cycle. The compound is incorporated into fluoroacetyl coenzyme A, which condenses with oxaloacetate to form fluorocitrate. This inhibits the enzyme aconitase, which inhibits conversion of citrate to cis-aconitic acid/isocitrate. This inhibition will lead to a buildup of citric acid resulting in convulsions and death from cardiac failure or respiratory arrest. Mitochondrial uptake of acetate may also be affected. The heart and CNS are the tissues most affected by this inhibition of oxidative energy metabolism. Oxygen consumption is markedly reduced. In addition to blockade of energy production, depletion of calcium may also be involved in the clinical manifestations associated with sodium fluoroacetate toxicity.`

https://www.sciencedirect.com/topics/earth-and-planetary-sciences/krebs-cycle

Answer 18

it cant be A and C so it has to be A and B

Answer 19

you're right about it being B because C says glycolysis ALONE, it would definitely use other mechanisms and pathways to try to replenish what it's losing from the malfunctional Krebs cycle

Answer 20

thanks

Answer 21

No problem!

Sorry if I overthought this question haha